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Article

C Protein Is Essential for Canine Distemper Virus Virulence and Pathogenicity in Ferrets

20 Nov 2020

Abstract excerpt

The measles (MeV) and canine distemper viruses (CDV) express accessory proteins that regulate the host immune response and enhance replication. The MeV C protein is critical in preventing the generation of excess immunostimulatory double-stranded RNA. C protein-deficient MeV is strongly attenuated compared to wild-type virus, whereas CDV with a similarly disrupted C open reading frame is fully pathogenic. Here we...

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PMID: 33239455
DOI: 10.1128/jvi.01840-20

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