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The Rift Valley fever accessory proteins NSm and P78/NSm-G <sub>N</sub> are distinct determinants of virus propagation in vertebrate and invertebrate hosts

1 Jan 2014

Abstract excerpt

Rift Valley fever virus (RVFV) is an enzootic virus circulating in Africa that is transmitted to its vertebrate host by a mosquito vector and causes severe clinical manifestations in humans and ruminants. RVFV has a tripartite genome of negative or ambisense polarity. The M segment contains five in-frame AUG codons that are alternatively used for the synthesis of two major structural glycoproteins, GN and GC, and...

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PMID: 26038497
DOI: 10.1038/emi.2014.71

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