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Article

Morbillivirus control of the interferon response: relevance of STAT2 and mda5 but not STAT1 for canine distemper virus virulence in ferrets.

Journal of virology - 1 Mar 2014

Svitek Nicholas, Gerhauser Ingo, Goncalves Christophe, Grabski Elena, Döring Marius, Kalinke Ulrich, Anderson Danielle E, Cattaneo Roberto, von Messling Veronika

Abstract excerpt

UNLABELLED: The V proteins of paramyxoviruses control the innate immune response. In particular, the V protein of the genus Morbillivirus interferes with the signal transducer and activator of transcription 1 (STAT1), STAT2, and melanoma differentiation-associated protein 5 (mda5) signaling pathways. To characterize the contributions of these pathways to canine distemper virus (CDV) pathogenesis, we took...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24371065
DOI: 10.1128/JVI.03076-13
PMCID: PMC3958063

Genes

STAT2
STAT1

Provenance

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Related research

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Morbillivirus control of the interferon response: relevance of STAT2 and mda5 but not STAT1 for canine distemper virus virulence in ferrets.PMID 24371065Read ↗

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Two Domains of the V Protein of Virulent Canine Distemper Virus Selectively Inhibit STAT1 and STAT2 Nuclear ImportSemantic proximity Read ↗

A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation.Semantic proximity Read ↗

Paramyxovirus strategies for evading the interferon responseSemantic proximity Read ↗

Canine Distemper Virus Spread and Transmission to Naive Ferrets: Selective Pressure on Signaling Lymphocyte Activation Molecule-Dependent Entry.Semantic proximity Read ↗

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