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Article

Pediatric Gliosarcoma With and Without Neurofibromatosis Type 1: A Whole-exome Comparison of 2 Patients.

Journal of pediatric hematology/oncology - 1 Nov 2021

Graham Richard T, Bell Erica H, Webb Amy, Zhao Yue, Timmers Cynthia, Fleming Jessica L, Sells Blake E, Robison Nathan J, Palmer Joshua D, Finlay Jonathan L, Chakravarti Arnab

Abstract excerpt

Gliosarcoma is rare among pediatric patients and among individuals with Neurofibromatosis Type 1 (NF1). Here we compare 2 pediatric gliosarcoma patients, one of whom has NF1. We performed whole-exome sequencing, methylation, and copy number analysis on tumor and blood for both patients. Whole-exome sequencing showed higher mutational burden in the tumor of the patient without NF1. Copy number analysis showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33235140
DOI: 10.1097/MPH.0000000000002020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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