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Article

Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation.

PLoS pathogens - 1 Nov 2020

Ekanayaka Pathum, Lee Seo-Yong, Herath Thilina U B, Kim Jae-Hoon, Kim Tae-Hwan, Lee Hyuncheol, Chathuranga Kiramage, Chathuranga W A Gayan, Park Jong-Hyeon, Lee Jong-Soo

Abstract excerpt

VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral immune responses. Previous studies show that amino acid changes in the VP1 protein of cell culture-adapted strains of FMDV alter the properties of the virus. In addition, FMDV VP1 modulates host IFN signal transduction. Here, we examined the ability of cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33232374
DOI: 10.1371/journal.ppat.1009057
PMCID: PMC7723281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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