Article
Genome-wide association study across pediatric central nervous system tumors implicates shared predisposition and points to 1q25.2 (PAPPA2) and 11p12 (LRRC4C) as novel candidate susceptibility loci.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Mar 2021
Foss-Skiftesvik Jon, Hagen Christian Munch, Mathiasen René, Adamsen Dea, Bækvad-Hansen Marie, Børglum Anders D, Nordentoft Merete, Werge Thomas, Christiansen Michael, Schmiegelow Kjeld, Juhler Marianne, Mortensen Preben Bo, Hougaard David Michael, Bybjerg-Grauholm Jonas
Abstract excerpt
INTRODUCTION: Central nervous system (CNS) tumors constitute the most common form of solid neoplasms in children, but knowledge on genetic predisposition is sparse. In particular, whether susceptibility attributable to common variants is shared across CNS tumor types in children has not been investigated. The purpose of this study was to explore potential common genetic risk variants exhibiting pleiotropic...
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