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Integrative analysis reveals novel driver genes and molecular subclasses of hepatocellular carcinoma.

Aging - 20 Nov 2020

Yang Liguang, Zhang Zhengtao, Sun Yidi, Pang Shichao, Yao Qianlan, Lin Ping, Cheng Jinming, Li Jia, Ding Guohui, Hui Lijian, Li Yixue, Li Hong

Abstract excerpt

Hepatocellular carcinoma (HCC) is a heterogeneous disease with various genetic and epigenetic abnormalities. Previous studies of HCC driver genes were primarily based on frequency of mutations and copy number alterations. Here, we performed an integrative analysis of genomic and epigenomic data from 377 HCC patients to identify driver genes that regulate gene expression in HCC. This integrative approach has...

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Identifiers

PMID: 33221766
DOI: 10.18632/aging.104047
PMCID: PMC7762459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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