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Article

Antibody-dependent enhancement (ADE) of dengue virus: Identification of the key amino acid that is vital in DENV vaccine research.

The journal of gene medicine - 1 Feb 2021

Cui Guohui, Si Lulu, Wang Ying, Zhou Junmei, Yan Huijun, Jiang Lifang

Abstract excerpt

BACKGROUND: The antibody-dependent enhancement (ADE) of dengue virus (DENV) has critically restricted vaccine development. Prior research suggested pr4 as the probable ADE epitope of DENV. METHODS: Chimeric DENV was constructed by replacing the DENV pr4 gene with the corresponding Japanese encephalitis virus (JEV) gene to determine whether it can reduce ADE activities. An alanine scanning method and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33217097
DOI: 10.1002/jgm.3297
PMCID: PMC7900978

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