Article
Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability.
The Biochemical journal - 11 Dec 2020
Wang Mengli, Lin Lin, Shi Yingdong, He Liping, Wang Chao, Zhu Jinwei
Abstract excerpt
Scaffold proteins play crucial roles in orchestrating synaptic signaling and plasticity in the excitatory synapses by providing a structural link between glutamatergic receptors, signaling molecules, and neuronal cytoskeletons. FRMPD4 is a neural scaffold protein that binds to metabotropic glutamate receptors via its FERM domain. Here, we determine the crystal structure of the FERM domain of FRMPD4 at 2.49 Å...
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