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Article

Evaluation of miR-302 promoter activity in transgenic mice and pluripotent stem cell lines.

In vitro cellular & developmental biology. Animal - 1 Dec 2020

Rahimi Karim, Parsa Sara, Nikzaban Mehrnoush, Khaledian Behnoush, Mowla Seyed Javad, Fathi Fardin

Abstract excerpt

Some miRNAs, including the miR-302 cluster, are critical regulators of the stemness state of embryonic stem cells and cell fate patterning. In this study, we evaluated the activity of the miR-302 core promotor in mice and human pluripotent stem cells, somatic tissue derivatives, and generated transgenic mice expressing EGFP under a miR-302 promoter. The expression of EGFP under the control of the miR-302 promotor...

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PMID: 33210246
DOI: 10.1007/s11626-020-00516-8

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