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Article

Anti-CENP-B polarity divides SLE: divergent clinical-immune phenotypes and distinct treatment responses.

Frontiers in immunology - 1 Jan 2026

Liu Xiaoli, Xiao Zhefeng, Yao Yuxing, Yuan Youhua, Zhang Xia, Li Jianfeng, Zhang Xiuzhi, Tian Xiaohui, An Lemei

Abstract excerpt

Background: Anti-CENP-B antibodies (anti-CENP-B), directed against centromere protein B, are a serological hallmark of limited cutaneous systemic sclerosis (lcSSc) but are only occasionally encountered in systemic lupus erythematosus (SLE). When detected in SLE they may create diagnostic ambiguity. Since autoantibody-defined SLE subsets exhibit distinct phenotypes, delineating the clinical and immunological...

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Identifiers

PMID: 41659860
DOI: 10.3389/fimmu.2026.1762899
PMCID: PMC12872543

Genes

CD19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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