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CRL4DCAF1 is required in activated oocytes for follicle maintenance and ovulation

3 Nov 2014

Abstract excerpt

In mammals, oocytes within the primordial follicles require a number of essential factors to maintain their survival. However, the survival factors for activated oocytes have been poorly characterized. Recently we reported that damaged DNA binding protein-1 (DDB1), the linker subunit of the cullin ring-finger ubiquitin E3 ligase-4 (CRL4) complex, and its substrate adaptor, DDB1-CUL4 associated factor-1 (DCAF1),...

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PMID: 25371539
DOI: 10.1093/molehr/gau103

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