Article
Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1-deficient Jack Russell Terriers and response to topical ceramide.
Veterinary dermatology - 1 Dec 2024
Mauldin Elizabeth, Bradley Charles, Casal Margret, Meyer Jason, Crumrine Debra, Kiener Sarah, Leeb Tosso, Elias Peter M
Abstract excerpt
BACKGROUND: Autosomal recessive ichthyosis leads to structural or biochemical changes that impair skin barrier function. HYPOTHESIS/OBJECTIVES: To assess (1) the phenotype and genotype in a litter of Jack Russell Terriers with autosomal recessive congenital ichthyosis (ARCI), and (2) the defective skin barrier and determine if a topical ceramide can modulate the barrier. ANIMALS: A healthy dam and litter of Jack...
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