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Article

Development of ichthyosiform skin compensates for defective permeability barrier function in mice lacking transglutaminase 1.

The Journal of clinical investigation - 1 Jan 2002

Kuramoto Nobuo, Takizawa Toshihiro, Takizawa Takami, Matsuki Masato, Morioka Hiroyuki, Robinson John M, Yamanishi Kiyofumi

Abstract excerpt

Transglutaminase 1 (TGase 1) is one of the genes implicated in autosomal recessive congenital ichthyosis. Skin from TGase 1(-/-) mice, which die as neonates, lacks the normal insoluble cornified envelope and has impaired barrier function. Characterization of in situ dye permeability and transepid...

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Identifiers

PMID: 11805136
DOI: 10.1172/JCI13563
PMCID: PMC150837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11805136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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