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Article

Identification of Novel Influenza Polymerase PB2 Inhibitors Using a Cascade Docking Virtual Screening Approach.

Molecules (Basel, Switzerland) - 13 Nov 2020

Zhao Lei, Che Jinjing, Zhang Qian, Li Yiming, Guo Xiaojia, Chen Lixia, Li Hua, Cao Ruiyuan, Li Xingzhou

Abstract excerpt

To discover novel inhibitors that target the influenza polymerase basic protein 2 (PB2) cap-binding domain (CBD), commercial ChemBridge compound libraries containing 384,796 compounds were screened using a cascade docking of LibDock-LigandFit-GOLD, and 60 compounds were selected for testing with cytopathic effect (CPE) inhibition assays and surface plasmon resonance (SPR) assay. Ten compounds were identified to...

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Identifiers

PMID: 33202790
DOI: 10.3390/molecules25225291
PMCID: PMC7697191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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