Article

Comprehensive profiling of mutations to influenza virus PB2 that confer resistance to the cap-binding inhibitor pimodivir

2021-05-11

Abstract excerpt

Antivirals are used not only in current treatment of influenza, but are also stockpiled as a first line of defense against novel influenza strains for which vaccines have yet to be developed. Identifying drug resistance mutations can guide clinical deployment of the antiviral, and additionally define the mechanisms of drug action and drug resistance. Pimodivir is a first-in-class inhibitor of the polymerase basic...

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Literature Corpus work: dcdf6d95-5e45-5f03-bb72-6803b17c9fcb
DOI: 10.1101/2021.05.11.443605

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