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Article

Genetic-variant hotspots and hotspot clusters in the human genome facilitating adaptation while increasing instability.

Human genomics - 19 Mar 2021

Long Xi, Xue Hong

Abstract excerpt

BACKGROUND: Genetic variants, underlining phenotypic diversity, are known to distribute unevenly in the human genome. A comprehensive understanding of the distributions of different genetic variants is important for insights into genetic functions and disorders. METHODS: Herein, a sliding-window scan of regional densities of eight kinds of germline genetic variants, including single-nucleotide-polymorphisms...

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DNA Copy Number Variations
DNA Replication
Genome, Human
Genomic Instability
Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

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PMID: 33741065
DOI: 10.1186/s40246-021-00318-3
PMCID: PMC7976700

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