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Article

Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length.

eLife - 13 Nov 2020

Shah Shanaya Shital, Hartono Stella, Piazza Aurèle, Som Vanessa, Wright William, Chédin Frédéric, Heyer Wolf-Dietrich

Abstract excerpt

Displacement loops (D-loops) are critical intermediates formed during homologous recombination. Rdh54 (a.k.a. Tid1), a Rad54 paralog in Saccharomyces cerevisiae, is well-known for its role with Dmc1 recombinase during meiotic recombination. Yet contrary to Dmc1, Rdh54/Tid1 is also present in somatic cells where its function is less understood. While Rdh54/Tid1 enhances the Rad51 DNA strand invasion activity in...

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Share to DNA, Fungal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33185188
DOI: 10.7554/eLife.59112
PMCID: PMC7695457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length.PMID 33185188Read ↗

Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin.Semantic proximity Read ↗

Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks.Semantic proximity Read ↗

ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54.Semantic proximity Read ↗

Novel attributes of Hed1 affect dynamics and activity of the Rad51 presynaptic filament during meiotic recombination.Semantic proximity Read ↗

Characterization of the interaction between the Saccharomyces cerevisiae Rad51 recombinase and the DNA translocase Rdh54.Semantic proximity Read ↗

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replicationSemantic proximity Read ↗

Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors.Semantic proximity Read ↗

Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homologue of RAD54, RDH54/TID1, in mitosis and meiosis.Semantic proximity Read ↗

Structural mechanism of strand exchange by the RAD51 filamentSemantic proximity Read ↗

Potential Rad54 separation of function mutation highlights unique roles during homologous recombination.Semantic proximity Read ↗

Rad51 paralog complex Rad55–Rad57 acts as a molecular chaperone during homologous recombinationSemantic proximity Read ↗

The translocation activity of Rad54 reduces crossover outcomes during homologous recombination.Semantic proximity Read ↗

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