Article
Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.
Diabetes care - 1 Jan 2021
Bowman Pamela, Mathews Frances, Barbetti Fabrizio, Shepherd Maggie H, Sanchez Janine, Piccini Barbara, Beltrand Jacques, Letourneau-Freiberg Lisa R, Polak Michel, Greeley Siri Atma W, Rawlins Eamon, Babiker Tarig, Thomas Nicholas J, De Franco Elisa, Ellard Sian, Flanagan Sarah E, Hattersley Andrew T
Abstract excerpt
OBJECTIVE: ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological features than those with KCNJ11-PNDM. However, these studies were short-term and included...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.