Article
Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers.
The Journal of clinical endocrinology and metabolism - 1 Apr 2007
Stanik Juraj, Gasperikova Daniela, Paskova Magdalena, Barak Lubomir, Javorkova Jana, Jancova Emilia, Ciljakova Miriam, Hlava Peter, Michalek Jozef, Flanagan Sarah E, Pearson Ewan, Hattersley Andrew T, Ellard Sian, Klimes Iwar
Abstract excerpt
CONTEXT: Mutations in the KCNJ11 and ABCC8 genes encoding the pancreatic beta-cell K(ATP) channel have recently been shown to be the most common cause of permanent neonatal diabetes mellitus (PNDM). Information regarding the frequency of PNDM has been based mainly on nonpopulation or short-term collections only. Thus, the aim of this study was to identify the incidence of PNDM in Slovakia and to switch patients...
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