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Article

Personalized medicine switching from insulin to sulfonylurea in permanent neonatal diabetes mellitus dictated by a novel activating ABCC8 mutation.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 2012

Mak Chloe Miu, Lee Ching-yin, Lam Ching-wan, Siu Wai-Kwan, Hung Vanessa Ching-ngar, Chan Albert Yan-wo

Abstract excerpt

BACKGROUND: Neonatal diabetes mellitus (NDM) is a rare but important condition affecting approximately 1 in 100,000 newborns. Permanent form requires life-long treatment with difficulties in long-term compliance and metabolic complications. Exact genetic diagnosis can enable improved outcome and patient satisfaction by switching insulin injection to oral sulfonylureas. Successful cases have been reported with...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Inwardly Rectifying

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Share to Receptors, Drug

Share to Sulfonylurea Receptors

Source

Identifiers

PMID: 22306677
DOI: 10.1097/PDM.0b013e318220bb0e

Genes

ABCC8
KCNJ11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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