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Article

A novel model of central precocious puberty disease: Paternal MKRN3 gene-modified rabbit.

Animal models and experimental medicine - 1 Mar 2025

Chen Bangzhu, Ye Xing, Chen Lihao, Liu Tianping, Li Guiling, Sa Chula, Li Juan, Liu Ke, Gu Weiwang, Wang Gang

Abstract excerpt

BACKGROUND: Makorin ring finger protein 3 gene (MKRN3) gene mutation is the most common genetic cause of central precocious puberty (CPP) in children. Due to the lack of ideal MKRN3-modified animal model (MKRN3-modified mice enter puberty only 4-5 days earlier than normal mice), the related research is limited. METHODS: Therefore, the MKRN3-modified rabbit was developed using CRISPR (clustered regularly...

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Source

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Identifiers

PMID: 39854156
DOI: 10.1002/ame2.12544
PMCID: PMC11904109

Genes

MKRN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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