Article
In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism.
Molecular medicine reports - 1 Jan 2021
Liu Songyao, Murakami Eisuke, Nakahara Takashi, Ohya Kazuki, Teraoka Yuji, Makokha Grace Naswa, Uchida Takuro, Morio Kei, Fujino Hatsue, Ono Atsushi, Yamauchi Masami, Kawaoka Tomokazu, Miki Daiki, Tsuge Masataka, Hiramatsu Akira, Abe-Chayama Hiromi, Hayes Nelson C, Imamura Michio, Aikata Hiroshi, Chayama Kazuaki
Abstract excerpt
Non‑alcoholic steatohepatitis (NASH) may progress via liver fibrosis along with hepatic stellate cell (HSC) activation. A single nucleotide polymorphism (SNP; rs58542926) located in transmembrane 6 superfamily 2 (TM6SF2) has been reported to be significantly associated with fibrosis in patients with NASH, but the precise mechanism is still unknown. The present study aimed to explore the role of TM6SF2 in HSC...
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