Article
Characterizing the Discordance between AT-Rich Interacting Domain 1A Protein and Genotype in Endometrioid-Type Endometrial Tumors.
The American journal of pathology - 1 Jul 2026
LaBuda Savannah E, Spence Katherine, Niranjan Rahul R, Weeranshige Isurika, Osborne-Frazier Macy L, Broaddus Russell R, Gladden Andrew B
Abstract excerpt
ARID1A is one of the most frequently mutated genes in endometrial cancer, with approximately 40% of patients harboring an ARID1A mutation. However, relatively little is known about how AT-rich interacting domain 1A (ARID1A) protein loss shapes endometrial cancer pathogenesis. Mounting evidence from other malignancies suggests that ARID1A protein can be regulated post-translationally, independent of genotype....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.