Article
Different immunization methods lead to altered gut flora and varied responses to Mycobacterium tuberculosis infection in mice.
Journal of infection in developing countries - 31 Oct 2020
Guo Jianguo, Tang Jun, Kang Taisheng, Xiong Yi, Xiang Zhiguang, Qin Chuan
Abstract excerpt
INTRODUCTION: Vaccination is an essential means for prevention of tuberculosis infection, but the effects of various vaccines on the intestinal flora of mice and their response to Mycobacterium tuberculosis (Mtb) infection remain poorly understood. METHODOLOGY: In this study, two different vaccinations - ESAT6 and ESAT6 + TLR8 agonists - were administered to mice transgenic for human TLR8 to investigate gut...
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