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Article

Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans.

JCI insight - 17 Dec 2020

Borén Jan, Adiels Martin, Björnson Elias, Matikainen Niina, Söderlund Sanni, Rämö Joel, Ståhlman Marcus, Ripatti Pietari, Ripatti Samuli, Palotie Aarno, Mancina Rosellina M, Hakkarainen Antti, Romeo Stefano, Packard Chris J, Taskinen Marja-Riitta

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation. The transmembrane 6 superfamily member 2 (TM6SF2) E167K genetic variant associates with NAFLD and with reduced plasma triglyceride levels in humans. However, the molecular mechanisms underlying these associations remain unclear. We hypothesized that TM6SF2 E167K affects hepatic very low-density lipoprotein (VLDL) secretion...

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Identifiers

PMID: 33170809
DOI: 10.1172/jci.insight.144079
PMCID: PMC7819740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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