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Article

The soluble cytoplasmic N-terminal domain of the FocA channel gates bidirectional formate translocation.

Molecular microbiology - 1 Apr 2021

Kammel Michelle, Hunger Doreen, Sawers Robert Gary

Abstract excerpt

FocA belongs to the pentameric FNT (formate-nitrite transporter) superfamily of anion channels, translocating formate bidirectionally across the cytoplasmic membrane of Escherichia coli and other microorganisms. While the membrane-integral core of FocA shares considerable amino acid sequence conservation with other FNT family members, the soluble cytoplasmic N-terminal domain does not. To analyze the potential...

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Identifiers

PMID: 33169422
DOI: 10.1111/mmi.14641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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