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Article

High level production of functional antibody Fab fragments in an oxidizing bacterial cytoplasm.

Journal of molecular biology - 4 Jan 2002

Venturi Miro, Seifert Claudia, Hunte Carola

Abstract excerpt

The antigen-binding fragments (Fab) of antibodies are powerful tools in clinical therapy, molecular diagnostics and basic research. However, their principal applications require pure recombinant molecules in large amounts, which are challenging to obtain. Severe limitations in yield, folding and functionality are commonly encountered in bacterial production of Fab fragments. Secretion into the oxidizing periplasm...

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Identifiers

PMID: 11771962
DOI: 10.1006/jmbi.2001.5221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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