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Episodic Aspiration with Oral Commensals Induces a MyD88-Dependent, Pulmonary T-Helper Cell Type 17 Response that Mitigates Susceptibility to Streptococcus Pneumoniae

9 Nov 2020

Abstract excerpt

Abstract Rationale Cross-sectional human data suggest that enrichment of oral anaerobic bacteria in the lung is associated with an increased T-helper cell type 17 (Th17) inflammatory phenotype. Objectives In this study, we evaluated the microbial and host immune-response dynamics after aspiration with oral commensals using a preclinical mouse model. Methods Aspiration with a mixture of human oral commensals (MOC;...

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PMID: 33166473
DOI: 10.1164/rccm.202005-1596oc

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