Article
Lower airway dysbiosis in nontuberculous mycobacteria-positive bronchiectasis is associated with neutrophil extracellular trap-predominant severe phenotypes.
American journal of respiratory and critical care medicine - 1 May 2026
Singh Shivani, Darawshy Fares, Erlandson Kirby, Narayana Jayanth Kumar, Li Qingsheng, Li Yonghua, Atandi Isabella, Krolikowski Kelsey, Patel Shrey, Collazo Destiny, Mac Aogáin Micheál, Gilmour Amy, Long Merete, Chang Miao, Hoque Afshana, Schluger Rosemary, Kumar Sanjan, Chung Cecilia J, Wong Kendrew, Porter Gabriella, Feng Yicheng, Czachor Anna, McCormick Colin, Clementi Emily, Kyeremateng Yaa, Lukovnikova Alena, Harris Danielle, Gomez Sebastian, Kain Taylor, Kocak Ibrahim, Singh Rajbir, Rodriguez Claudia, Kwok Benjamin, Barnett Clea, Kugler Matthias, Weiden Michael D, Nelson Nathaniel, Natalini Jake G, Luglio David, Desvignes Ludovic, Gautam Samir, McGuire Erin, Gordon Terry, Sulaiman Imran, Tsay Jun-Chieh J, Basavaraj Ashwin, Wu Benjamin G, Kamelhar David, Addrizzo-Harris Doreen, Chalmers James D, Chotirmall Sanjay H, Segal Leopoldo N
Abstract excerpt
RATIONALE: The discoveries of neutrophilic inflammation and Pseudomonas-dominant pulmonary dysbiosis have helped pave the way for host-directed therapy in bronchiectasis. Substantial knowledge gaps still remain about the interplay between neutrophilic signatures and microbes in nontuberculous mycobacterial lung disease (NTM-LD), a phenotypically diverse lung infection that is increasingly prevalent in the United...
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