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Article

Association of Exon 14 of the SOX6 Gene Sequence Variations with Response to Hydroxyurea Therapy in Patients Carrying Non Transfusion-Dependent Thalassemia.

Hemoglobin - 1 Nov 2020

Mohammadi Zahra, Mohammadi Reza, Haghpanah Sezaneh, Moghadam Mohamad, Pazhoomand Reza, Karimi Mehran

Abstract excerpt

Hydroxyurea (HU) activates the γ-globin gene, resulting in increased Hb F synthesis. The SOX6 gene is a member of the Sox (Sry-type HMG box) family of transcription factors, characterized by minor groove binding domain. The DNA binding domain of this gene is encoded by exon 14. We assessed the relationship between response to HU and exon 14 of the SOX6 gene sequence variations in patients with non...

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Identifiers

PMID: 33164584
DOI: 10.1080/03630269.2020.1845722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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