Article
Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients.
Haematologica - 1 Oct 2004
Yavarian Majid, Karimi Mehran, Bakker Egbert, Harteveld Cornelis L, Giordano Piero C
Abstract excerpt
BACKGROUND AND OBJECTIVES: Hydroxyurea (HU) is known to increase gamma-globin chain expression in postnatal life. The efficacy of HU treatment in thalassemia patients is still unclear. The aim of this study was to monitor treatment of a large cohort of patients with beta-thalassemia major in order to establish the response to HU and the associated elements. DESIGN AND METHODS: HU therapy was started in 133...
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