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Article

Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities.

Nature communications - 6 Nov 2020

Rix Gordon, Watkins-Dulaney Ella J, Almhjell Patrick J, Boville Christina E, Arnold Frances H, Liu Chang C

Abstract excerpt

Enzyme orthologs sharing identical primary functions can have different promiscuous activities. While it is possible to mine this natural diversity to obtain useful biocatalysts, generating comparably rich ortholog diversity is difficult, as it is the product of deep evolutionary processes occurring in a multitude of separate species and populations. Here, we take a first step in recapitulating the depth and...

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Identifiers

PMID: 33159067
DOI: 10.1038/s41467-020-19539-6
PMCID: PMC7648111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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