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Continuous Directed Evolution of a Short-Lived Plant Histidinol Dehydrogenase.

ACS synthetic biology - 20 Mar 2026

Oliveira-Filho Edmar R, Gayen Anuran K, Leong Bryan J, Belt Katharina, Voiniciuc Cătălin, Millar A Harvey, Hanson Andrew D

Abstract excerpt

Enzyme protein turnover accounts for about half the maintenance energy budget in plants. Slowing turnover─i.e., extending the effective working life (Catalytic Cycles till Replacement, CCR)─of short-lived enzymes is thus a rational strategy to conserve energy and carbon and raise crop productivity. Arabidopsis histidinol dehydrogenase (HDH) is a short-lived enzyme that can sustain life-shortening damage from its...

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PMID: 41688052
DOI: 10.1021/acssynbio.5c00468
PMCID: PMC13010363

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