CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy.

doi:10.1590/0074-02760200110

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Article

CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy.

Memorias do Instituto Oswaldo Cruz - 1 Jan 2020

Costa Germano Carneiro, Rocha Manoel Otávio da Costa, Souza Paulo Eduardo Alencar de, Melo Diego Felipe Sa, Moreira Paula Rocha, Gollob Kenneth John, Nunes Maria do Carmo Pereira, Dutra Walderez Ornelas

Abstract excerpt

We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14-...

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PMID: 33146244
DOI: 10.1590/0074-02760200110
PMCID: PMC7592494

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