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Article

The novel function of miR-3195 for mutant PROK2 (c.223-4C>A) degradation.

Cell biology international - 1 Feb 2021

Zhou Shasha, Li Pin

Abstract excerpt

Kallmann syndrome (KS) is a rare human genetic disorder characterized by hypogonadotropic hypogonadism with the reduction or absence of olfactory sense. Mutations in multiple genes, including chemokine prokineticin-2 (PROK2), are considered to contribute to the abnormal migration of gonadotropin-releasing hormone neurons in the embryonic stage. However, the mechanisms of the different inheritance modes of KS have...

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PMID: 33140874
DOI: 10.1002/cbin.11496

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