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Article

Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.

Endocrine journal - 28 Jul 2022

Sugisawa Chiho, Taniyama Matsuo, Sato Takeshi, Takahashi Yasuyoshi, Hasegawa Tomonobu, Narumi Satoshi

Abstract excerpt

Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder that causes gonadotropin-releasing hormone (GnRH) deficiency and sexual immaturity. CHH may accompany an abnormal sense of smell (Kallmann syndrome, KS) or no such manifestation (normosmic-CHH). This unusual combination of manifestations is explained by the fact that GnRH neurons originate in the olfactory placode and migrate to the forebrain...

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Identifiers

PMID: 35236788
DOI: 10.1507/endocrj.EJ21-0779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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