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Article

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma.

Clinical epigenetics - 2 Nov 2020

Alberge Jean-Baptiste, Magrangeas Florence, Wagner Mirko, Denié Soline, Guérin-Charbonnel Catherine, Campion Loïc, Attal Michel, Avet-Loiseau Hervé, Carell Thomas, Moreau Philippe, Minvielle Stéphane, Sérandour Aurélien A

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observed at particular regions of myeloma such as B cell-specific enhancers. The recently discovered active epigenetic mark 5-hydroxymethylCytosine (5hmC) may also play a role in tumor biology;...

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Identifiers

PMID: 33138842
DOI: 10.1186/s13148-020-00953-y
PMCID: PMC7607866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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