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Article

TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.

PLoS genetics - 1 Nov 2020

Pataki Emese, Simhaev Luba, Engel Hamutal, Cohen Adiel, Kupiec Martin, Weisman Ronit

Abstract excerpt

The Target of rapamycin (TOR) protein kinase forms part of TOR complex 1 (TORC1) and TOR complex 2 (TORC2), two multi-subunit protein complexes that regulate growth, proliferation, survival and developmental processes by phosphorylation and activation of AGC-family kinases. In the fission yeast, Schizosaccharomyces pombe, TORC2 and its target, the AGC kinase Gad8 (an orthologue of human AKT or SGK1) are required...

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Identifiers

PMID: 33137119
DOI: 10.1371/journal.pgen.1009196
PMCID: PMC7660925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.PMID 33137119Read ↗

Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases.Semantic proximity Read ↗

Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle controlSemantic proximity Read ↗

Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.Semantic proximity Read ↗

TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.Semantic proximity Read ↗

Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes.Semantic proximity Read ↗

The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.Semantic proximity Read ↗

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Semantic proximity Read ↗

Structure-based engineering of Tor complexes uncovers different roles of two types of yeast TORC1sSemantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

Critical role of Wat1/Pop3 in regulating the TORC1 signalling pathway in fission yeast S. pombeSemantic proximity Read ↗

Protein phosphatase 2C acts independently of stress-activated kinase cascade to regulate the stress response in fission yeast.Semantic proximity Read ↗

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.Semantic proximity Read ↗

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