Article
Mitochondrial tRNA variants in Chinese subjects with coronary heart disease.
Journal of the American Heart Association - 27 Jan 2014
Qin Yanwen, Xue Ling, Jiang Pingping, Xu Meifen, He Yiqun, Shi Suxue, Huang Yangyiyi, He Jiqiang, Mo Jun Qin, Guan Min-Xin
Abstract excerpt
BACKGROUND: Coronary heart disease is the leading cause of death worldwide. Mitochondrial genetic determinants for the development of this disorder remain less explored. METHODS AND RESULTS: We performed a clinical and genetic evaluation and mutational screening of 22 mitochondrial tRNA genes in a cohort of 80 genetically unrelated Han Chinese subjects and 125 members of 4 families with coronary heart disease and...
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