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G protein pathway suppressor 2 suppresses gastric cancer by destabilizing epidermal growth factor receptor

7 Oct 2021

Abstract excerpt

G protein pathway suppressor 2 (GPS2) is expressed in most human tissues, including the stomach. However, the biological functions of GPS2 in cancer, as well as the underlying molecular mechanisms, remain poorly understood. Here, we report that GPS2 expression was aberrantly downregulated in gastric cancer (GC) tissues compared with control tissues. Clinicopathologic analysis showed that low GPS2 expression was...

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PMID: 34609770
DOI: 10.1111/cas.15151

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