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Article

Gankyrin sustains PI3K/GSK-3β/β-catenin signal activation and promotes colorectal cancer aggressiveness and progression.

Oncotarget - 6 Dec 2016

He Feng, Chen Huacui, Yang Ping, Wu Qianlong, Zhang Tong, Wang Chengxing, Wei Jianchang, Chen Zhuanpeng, Hu He, Li Wanglin, Cao Jie

Abstract excerpt

High levels of angiogenesis, metastasis and chemoresistance are major clinical features of colorectal cancer (CRC), a lethal disease with a high incidence worldwide. Aberrant activation of Wnt/β-catenin pathway contributes to CRC progression. However, little is known about regulatory mechanisms of the β-catenin activity in cancer progression. Here we report that Gankyrin was markedly upregulated in primary tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27835604
DOI: 10.18632/oncotarget.13215
PMCID: PMC5348383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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