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Subcellular localization of HMGB1 in colorectal cancer impacts on tumor grade and survival prognosis

29 Oct 2020

Abstract excerpt

The high-mobility group box-1 (HMGB1) protein is implicated in the development of various cancers and their proliferation. According to its function, HMGB1 shuttles between the cell nucleus and cytoplasm, assisting with nucleosome stabilization and gene transcription, or localizing in the cell membrane for outgrowth. The clinicopathologic and prognostic significance of these different subcellular locations and...

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PMID: 33122771
DOI: 10.1038/s41598-020-75783-2

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