Article
Human Papillomavirus G-Rich Regions as Potential Antiviral Drug Targets.
Nucleic acid therapeutics - 1 Feb 2021
Carvalho Josué, Lopes-Nunes Jéssica, Campello Maria Paula Cabral, Paulo António, Milici Janice, Meyers Craig, Mergny Jean-Louis, Salgado Gilmar F, Queiroz João A, Cruz Carla
Abstract excerpt
Herein, we report, for the first time, the screening of several ligands in terms of their ability to bind and stabilize G-quadruplexes (G4) found in seven human Papillomavirus (HPV) genomes. Using a variety of biophysical assays, HPV G-quadruplexes were shown to possess a high degree of structural polymorphism upon ligand binding, which may have an impact on transcription, replication, and viral protein...
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