The impact of MYC and BCL2 structural variants in tumors of DLBCL morphology and mechanisms of false-negative MYC IHC.

doi:10.1182/blood.2020007193

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Article

The impact of MYC and BCL2 structural variants in tumors of DLBCL morphology and mechanisms of false-negative MYC IHC.

Blood - 22 Apr 2021

Collinge Brett, Ben-Neriah Susana, Chong Lauren, Boyle Merrill, Jiang Aixiang, Miyata-Takata Tomoko, Farinha Pedro, Craig Jeffrey W, Slack Graham W, Ennishi Daisuke, Mottok Anja, Meissner Barbara, Chavez Elizabeth A, Gerrie Alina S, Villa Diego, Freeman Ciara, Savage Kerry J, Sehn Laurie H, Morin Ryan D, Mungall Andrew J, Gascoyne Randy D, Marra Marco A, Connors Joseph M, Steidl Christian, Scott David W

Abstract excerpt

When the World Health Organization defined high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) as a clinical category, rearrangements were the only structural variant (SV) incorporated. An "atypical double-hit" category has been proposed, encompassing tumors with concurrent MYC and BCL2 SVs other than cooccurring translocations (ie, copy number variations [CNVs]). Although the...

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PMID: 33120427
DOI: 10.1182/blood.2020007193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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