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Article

TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations.

Leukemia & lymphoma - 1 Jan 2015

Gebauer Niklas, Bernard Veronica, Gebauer Wolfgang, Thorns Christoph, Feller Alfred C, Merz Hartmut

Abstract excerpt

Double-hit lymphomas (DHL) with MYC and either BCL2 or BCL6 rearrangements are rare neoplasms with an aggressive clinical presentation and grim prognosis. Moreover, molecular characterization of DHL remains insufficient, and especially the role of TP53 pathway disruption is unknown. We employed a next-generation sequencing approach to investigate the mutational status of TP53 in DHL and correlated genomic data...

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Topics

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Share to Cell Transformation, Neoplastic
Share to Genes, myc

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Immunohistochemistry

Share to Lymphoma, B-Cell

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-bcl-6

Share to Translocation, Genetic

Source

Identifiers

PMID: 24679006
DOI: 10.3109/10428194.2014.907896

Genes

MYC
BCL2
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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