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Article

Functional genetic variant of HSD17B12 in the fatty acid biosynthesis pathway predicts the outcome of colorectal cancer.

Journal of cellular and molecular medicine - 1 Dec 2020

Lin Yu, Meng Yixuan, Zhang Jinying, Ma Ling, Jiang Lu, Zhang Yi, Yuan Ming, Ren Anjing, Zhu Weiyou, Li Shuwei, Shu Yongqian, Du Mulong, Zhu Lingjun

Abstract excerpt

Fatty acids are involved in the development and progression of colorectal cancer (CRC). However, genetic effects of fatty acid biosynthesis pathway on CRC outcome are unclear. Cox regression model was used to evaluate genetic effects on CRC overall survival (OS) and progression-free survival (PFS), accompanied by calculating hazard ratios (HRs) and confidence intervals (CIs). Differential expression analysis,...

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17-Hydroxysteroid Dehydrogenases
Biosynthetic Pathways
Databases, Nucleic Acid
Fatty Acids
Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

Transcriptional Activation

YY1 Transcription Factor

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Identifiers

PMID: 33118286
DOI: 10.1111/jcmm.16026
PMCID: PMC7754038

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