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BRIP-1 germline mutation and its role in colon cancer: presentation of two case reports and review of literature

7 May 2019

Abstract excerpt

BACKGROUND: Hereditary colon cancer is characterized by the inheritance of an abnormal gene mutation which predisposes to malignancy. Recent advances in genomic medicine have identified mutations in "novel" genes as conferring an increased risk of colorectal cancer. Mutations in the BRIP1 gene (BRCA1 Interacting Protein C- terminal helicase 1) are known to increase the risk of ovarian and breast cancers, but this...

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PMID: 31064327
DOI: 10.1186/s12881-019-0812-0

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