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Article

Activity-Based Protein Profiling Reveals Potential Dasatinib Targets in Gastric Cancer.

International journal of molecular sciences - 4 Dec 2020

Choi Kyoung-Min, Cho Eunji, Bang Geul, Lee Seong-Jae, Kim Boram, Kim Ji-Hee, Park Seo-Gyu, Han Eun Hee, Chung Young-Ho, Kim Jin Young, Kim Eunjung, Kim Jae-Young

Abstract excerpt

Dasatinib is a multi-target kinase inhibitor, whose targets include BCR-ABL, SRC family kinases, and various cancer kinases. The elevated SRC activity in gastric cancer (GC) has prompted the need for the therapeutic application of dasatinib in GC. We observed that the efficacy of dasatinib varied with the GC cell lines. The differential effect of dasatinib was not correlated with the basal SRC activity of each...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33291786
DOI: 10.3390/ijms21239276
PMCID: PMC7729964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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