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Article

SDHx and Non-Chromaffin Tumors: A Mediastinal Germ Cell Tumor Occurring in a Young Man with Germline SDHB Mutation.

Medicina (Kaunas, Lithuania) - 25 Oct 2020

De Filpo Giuseppina, Cilotti Antonio, Rolli Luigi, Pastorino Ugo, Sonzogni Angelica, Pradella Silvia, Cantini Giulia, Ercolino Tonino, Nesi Gabriella, Mannelli Massimo, Maggi Mario, Canu Letizia

Abstract excerpt

Background: Mutations in genes encoding one of the subunits of succinate dehydrogenase (SDH) are involved in pheochromocytoma (PHEO) and paraganglioma (PGL) development. Over the last few years, such mutations have also been associated with non-chromaffin tumors. However, immunohistochemistry (IHC) on the tumor tissue and a study on the loss of heterozygosity (LOH) aimed at demonstrating the pathogenic role of...

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Identifiers

PMID: 33113876
DOI: 10.3390/medicina56110561
PMCID: PMC7693473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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